Listed below is a summary of the 10 most-referenced articles published by Dr. Elefteriades and the aortic research team:
Selected for Faculty of 1000 Medicine as one of most important articles published in medicine.
Percy A, Widman S, Rizzo JA, Tranquilli M, Elefteriades JA.
Deep hypothermic circulatory arrest (DHCA) is the practice of packing a patient's head in ice in order to let the surgeon operate in a bloodless field. The deep hypothermic arrest keeps brain activity at a minimum. DHCA has become an accepted practice for the purpose of short-to moderate duration cerebral protection, without the effects of impaired mental or physical functioning. Evidence provided by direct patient feedback shows that patients who undergo aortic surgery using DHCA experience no change in their cognitive abilities. The quality of work demonstrated by patients who undergo DHCA and those who do not offers no significant differences. Varying age groups, DHCA duration periods and genders do not offer contrasting results after DHCA as well. Although results do not support prolonged DHCA, they do show that high-cognitive patients who have had short-to moderate durations of DHCA show no change in overall cognitive abilities.
Ann Thorac Surg. 87(1):117-23, 2009.
Davies RR, Kaple RK, Mandapati D, Gallo A, Botta DM Jr, Elefteriades JA, Coady MA.
Ascending aortic aneurysms, when coupled with a bicuspid aortic valve, present with a faster rate of growth. The presence of a bicuspid aortic valve is a congenital defect, meaning it was present at birth, and is different from a normal aortic valve because it has 2 cusps rather than the 3 cusps of a trileaflet aortic valve. It is not unusual for individuals with bicuspid aortic valves to develop a dilatation of the aortic root and/or ascending aorta. When faced with aortic stenosis, aneurysmal patients with bicuspid aortic valves have a significant added risk. Patients with bicuspid aortic valves have similar rates of aortic rupture, dissection, and death, along with improved long-term survival when compared to patients with normally functioning aortic valves.
Ann Thorac Surg. 83(4):1338-44, 2007.
Elefteriades JA, Tranquilli M, Darr U, Cardon J, Zhu BQ, Barrett P.
This article documents a case study indicating that a symptomatic individual with significant family history should be approached with resection in mind, regardless of the size of the aneurysm. Size criteria are designed for use in the case of an asymptomatic patient diagnosed with a thoracic aortic aneurysm.
Ann Thorac Surg. 80(3):1098-100, 2005.